The upcoming Konami title will likely be the first on the market to use the super-sized DS card.
Konami Japan has announced that Tokemeki Memorial: Girl's Side 3rd Story, another entry in the venerable visual novel series, will be one of the first DS titles to use a 4-Gigabit (512-Megabyte) DS card.
Level 5's Ni no Kuni is also set to use a 4-Gigabit card, and may very well ship before 3rd Story's summer date, but it's unclear if the game will actually hit its scheduled spring release.
No titles using the new 4-Gigabit cards have been announced for North America.